Life Science Team Publishes Paper on Cancer Metabolism in Nature Communications

Modified: 12/09/2016

Source: School of Life Science and Biotechnology

Author: The News Center

A team from the School of Life Science and Biotechnology published a paper on Sept. 1 in Nature Communications, an international comprehensive scholarly journal, that is a breakthrough in research on T-cell acute lymphoblastic leukemia (T-ALL) cells energy metabolism research. Wenbin Zhong, a doctoral student at Jinan University, is the first author and Prof. Daoguang Yan is the project leader.

(Nature Communications published research findings of Prof. Daoguang Yan’s team online.)

Cancer cells requires abnormally high energy metabolism to proliferate and migrate. Yan’s team discovered that ORPL4, a member of the oxysterol binding proteins family, is essential for T-cell energy maintenance. The team has applied for patents for related research results.

This work was supported by grants from the Major Research Plan of the National Natural Science Foundation of China(Project 973), the National Basic Research Program of China and JNU’s Scientific Cultivation and Major Projects of Innovation Fund.


ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival : Nature Communications : Nature Research